Targeting metabolism to regulate immune responses in autoimmunity and cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/s41573-019-0032-5.pdf
Reference198 articles.
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2. Frauwirth, K. A. et al. The CD28 signaling pathway regulates glucose metabolism. Immunity 16, 769–777 (2002). This seminal article was one of the first to demonstrate a critical role for co-stimulation in the form of CD28 signalling to regulate metabolic reprogramming on T cell activation.
3. Zheng, Y. et al. A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J. Immunol. 178, 2163–2170 (2007).
4. Zheng, Y., Delgoffe, G. M., Meyer, C. F., Chan, W. & Powell, J. D. Anergic T cells are metabolically anergic. J. Immunol. 183, 6095–6101 (2009). This report demonstrated that on rechallenge, anergic T cells fail to upregulate metabolic programmes necessary for activation, suggesting that metabolism may in part be responsible for maintaining the anergic state.
5. Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871–882 (2011). Initial T cell activation and proliferation leads to a dramatic demand for energy and biosynthetic precursors that is facilitated by increased glycolysis, glutamine oxidation and nucleotide synthesis. This report demonstrates that these metabolic processes are coordinated by the upregulation of MYC.
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