Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.nature.com/articles/s41573-022-00493-5.pdf
Reference217 articles.
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2. Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027–1034 (2000). This article reports that PDL1 could interact with PD1 to inhibit T cell activity.
3. Dong, H. et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8, 793–800 (2002). This is the first paper to demonstrate that PDL1 expressed on tumour cells induces immune evasion by suppressing T cells, that PDL1 can be upregulated by IFNγ, and finally, it also shows the therapeutic effect of an antibody that blocks the PD1–PDL1 interaction.
4. Dong, H. et al. B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes. Immunity 20, 327–336 (2004).
5. Parish, C. R. Cancer immunotherapy: the past, the present and the future. Immunol. Cell Biol. 81, 106–113 (2003).
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