Abstract
AbstractPhotodynamic therapy (PDT), which utilizes light excite photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention in the last decades due to its unique advantages. However, the advancement of PDT is restricted by the inherent characteristics of PS and tumor microenvironment (TME). It is urgent to explore high-performance PSs with TME regulation capability and subsequently improve the therapeutic outcomes. Herein, we reported a newly engineered PS of polymer encapsulated carbonized hemin nanoparticles (P-CHNPs) via a facile synthesis procedure for boosting photodynamic anticancer therapy. Solvothermal treatment of hemin enabled the synthesized P-CHNPs to enhance oxidative stress in TME, which could be further amplified under light irradiation. Excellent in vitro and in vivo PDT effects were achieved due to the improved ROS (hydroxyl radicals and singlet oxygen) generation efficiency, hypoxia relief, and glutathione depletion. Moreover, the superior in vitro and in vivo biocompatibility and boosted PDT effect make the P-CHNPs a potential therapeutic agent for future translational research.
Funder
National Natural Science Foundation of China
Ministry of Science and Technology of the People’s Republic of China
Shanghai Jiao Tong University
Science and Technology Commission of Shanghai Municipality
Shanghai Municipal Education Commission
Publisher
Springer Science and Business Media LLC
Subject
Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials
Reference52 articles.
1. Wild, C. P., Weiderpass, E. & Stewart, B. W.World Cancer Report: Cancer Research for Cancer Prevention (International Agency for Research on Cancer, 2020).
2. Yin, F. et al. Functionalized 2D nanomaterials for gene delivery applications. Coord. Chem. Rev. 347, 77–97 (2017).
3. Ding, S. H. et al. Near-infrared light excited photodynamic anticancer therapy based on UCNP@AIEgen nanocomposite. Nanoscale Adv. 3, 2325–2333 (2021).
4. Pang, W. et al. Nucleolus-targeted photodynamic anticancer therapy using renal-clearable carbon dots. Adv. Healthc. Mater. 9, 2000607 (2020).
5. Dougherty, T. J. et al. Photodynamic therapy. J. Natl Cancer Inst. 90, 889–905 (1998).
Cited by
27 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献