Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress

Author:

Vallelian F,Deuel J W,Opitz L,Schaer C A,Puglia M,Lönn M,Engelsberger W,Schauer S,Karnaukhova E,Spahn D R,Stocker R,Buehler P W,Schaer D J

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Reference34 articles.

1. Schaer DJ, Buehler PW . Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies. Cold Spring Harb Perspect Med 2013; 3: 1569–1579.

2. Balla G, Vercellotti G, Eaton JW, Jacob HS . Heme uptake by endothelium synergizes polymorphonuclear granulocyte-mediated damage. Trans Assoc Am Physicians 1990; 103: 174–179.

3. Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM . Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 2013; 121: 1276–1284.

4. Boretti FS, Buehler PW, D'Agnillo F, Kluge K, Glaus T, Butt OI et al. Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest 2009; 119: 2271–2280.

5. Balla J, Jacob HS, Balla G, Nath K, Vercellotti GM . Endothelial cell heme oxygenase and ferritin induction by heme proteins: a possible mechanism limiting shock damage. Trans Assoc Am Physicians 1992; 105: 1–6.

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