Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l

Author:

Chen L,Deshpande A J,Banka D,Bernt K M,Dias S,Buske C,Olhava E J,Daigle S R,Richon V M,Pollock R M,Armstrong S A

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference33 articles.

1. Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R et al. The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Blood 1995; 86: 2073–2076.

2. Beverloo HB, Le Coniat M, Wijsman J, Lillington DM, Bernard O, de Klein A et al. Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis. Cancer Res 1995; 55: 4220–4224.

3. Bohlander SK, Muschinsky V, Schrader K, Siebert R, Schlegelberger B, Harder L et al. Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients. Leukemia 2000; 14: 93–99.

4. Dreyling MH, Schrader K, Fonatsch C, Schlegelberger B, Haase D, Schoch C et al. MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis. Blood 1998; 91: 4662–4667.

5. Yu BD, Hess JL, Horning SE, Brown GA, Korsmeyer SJ . Altered Hox expression and segmental identity in Mll-mutant mice. Nature 1995; 378: 505–508.

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