Heterozygotes for the ΔF508 cystic fibrosis allele are not protected against bronchial asthma

Author:

Mennie Moira,Gilfillan Annette,Brock David J.H.,Liston W. A.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference5 articles.

1. Schroeder, S.A., Gaughan, D.M. & Swift, M. Protection against bronchial asthma by CFTR ΔF508 mutation: A heterozygote advantage in cystic fibrosis. Nature Medicine 1, 703–705. (1995).

2. Mennie, M.F. et al. Prenatal screening for cystic fibrosis. Lancet 340, 214–217. (1992).

3. Meyers, D.A. & Marsh, D.G. Allergy and asthma. in The Genetic Basis of Common Diseases (eds King, R.A., Rotter, J.I. & Motulsky, A.G.) 130 (Oxford University Press, Oxford, 1992).

4. Capewell, S. Asthma in Scotland: epidemiology and clinical management. Health Bulletin 51, 118–127 (1993).

5. Livingstone, J. et al. Antenatal screening for cystic fibrosis: A trial of the couple model. Br. Med. J. 308, 1459–1462. (1994).

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