Split complementation of base editors reduces off-target edits
Author:
Publisher
Springer Science and Business Media LLC
Subject
Plant Science
Link
https://www.nature.com/articles/s41477-023-01548-0.pdf
Reference5 articles.
1. Zhang, H., Li, T., Sun, Y. & Yang, H. Perfecting targeting in CRISPR. Annu. Rev. Genet. 55, 453–477 (2021). A review article that provides an overview of CRISPR-based technologies and solutions to alleviate off-target effects.
2. Zuo, E. et al. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science 364, 289–292 (2019). This paper reports substantial genome-wide off-target edits by a CBE in mouse embryos.
3. Jin, S. et al. Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science 364, 292–295 (2019). This paper reports substantial genome-wide off-target edits by a CBE in transgenic rice.
4. Grünewald et al. Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors. Nature 569, 433–437 (2019). This paper reports that both CBE and ABE can induce substantial transcriptome-wide off-target edits in human cells.
5. Wang, Y., Zhou, L., Liu, N. & Yao, S. BE-PIGS: a base-editing tool with deaminases inlaid into Cas9 PI domain significantly expanded the editing scope. Signal Transduct. Target. Ther. 4, 36 (2019). This paper reports a CBE with a nCas9-inlaid cytidine deaminase.
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