Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population

Author:

Anderson David E.,Bieganowska Katarzyna D.,Bar-Or Amit,Oliveira Enedina M.L.,Carreno Beatriz,Collins Mary,Hafler David A.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference21 articles.

1. Lenschow, D.J., Walunas, T.L. & Bluestone, J.A. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14, 233–258 (1996).

2. Thompson, C.B. & Allison, J.P. The emerging role of CTLA-4 as an immune attenuator. Immunity 7, 445–450 (1997).

3. Morton, P.A., Loh, D.Y., Bluestone, J.A. & Jenkins, M.K. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155, 1032–1036 (1995).

4. Walunas, T.L. & Bluestone, J.A. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J. Immunol. 160, 3855–3860 (1998).

5. Kwon, E.D. et al. Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc. Natl. Acad. Sci. USA 94, 8099–8103 (1997).

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