Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation-Reference-Cited by-同舟云学术

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Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation

Published:2012-04-15 Issue:5 Volume:19 Page:532-537
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Musille Paul M,Pathak Manish C,Lauer Janelle L,Hudson William H,Griffin Patrick R,Ortlund Eric A

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb.2279.pdf

Reference38 articles.

1. Lee, J.M. et al. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474, 506–510 (2011).

2. Ortlund, E.A. et al. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat. Struct. Mol. Biol. 12, 357–363 (2005).

3. Krylova, I.N. et al. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell 120, 343–355 (2005).

4. Li, Y. et al. Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. Proc. Natl. Acad. Sci. USA 102, 9505–9510 (2005).

5. Fernandez-Marcos, P.J., Auwerx, J. & Schoonjans, K. Emerging actions of the nuclear receptor LRH-1 in the gut. Biochim. Biophys. Acta 1812, 947–955 (2011).

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