Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease-Reference-Cited by-同舟云学术

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Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease

Published:2002-10-15 Issue:11 Volume:8 Page:1270-1275
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Hock Christoph,Konietzko Uwe,Papassotiropoulos Andreas,Wollmer Axel,Streffer Johannes,von Rotz Ruth C.,Davey Gabriela,Moritz Eva,Nitsch Roger M.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm783.pdf

Reference30 articles.

1. Selkoe, D.J. Alzheimer's disease: Genes, proteins, and therapy. Physiol. Rev. 81, 741–766 (2001).

2. Schenk, D., Games, D. & Seubert, P. Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Aβ immunization. J. Mol. Neurosci. 17, 259–267 (2001).

3. Walsh, D.M. et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535–539 (2002).

4. Chen, G.Q. et al. A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease. Nature 408, 975–979 (2000).

5. Geula, C. et al. Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nature Med. 4, 827–831 (1998).

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