Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes accelerates the development of myelofibrosis-Reference-Cited by-同舟云学术

Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes accelerates the development of myelofibrosis

Published:2024-02-20 Issue:4 Volume:38 Page:898-902
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Duparc Hélène,Muller Delphine,Gilles Laure,Chédeville Agathe L.,El Khoury Mira,Guignard Rose,Debili Najet,Wittner Monika,Kauskot Alexandre^ORCID,Pasquier Florence,Antony-Debré Iléana^ORCID,Marty Caroline^ORCID,Vainchenker William^ORCID,Plo Isabelle^ORCID,Raslova Hana^ORCID

Funder

Ligue Nationale Contre le Cancer

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41375-024-02170-5.pdf

Reference15 articles.

1. Akada H, Yan D, Zou H, Fiering S, Hutchison RE, Mohi MG. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood. 2010;115:3589–97.

2. Hasan S, Lacout C, Marty C, Cuingnet M, Solary E, Vainchenker W, et al. JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNalpha. Blood. 2013;122:1464–77.

3. Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3:e270.

4. Lacout C, Pisani DF, Tulliez M, Gachelin FM, Vainchenker W, Villeval JL. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood. 2006;108:1652–60.

5. Marty C, Pecquet C, Nivarthi H, El-Khoury M, Chachoua I, Tulliez M, et al. Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis. Blood. 2016;127:1317–24.