LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML-Reference-Cited by-同舟云学术

LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

Published:2019-01-24 Issue:6 Volume:33 Page:1411-1426
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Barth Jessica,Abou-El-Ardat Khalil,Dalic Denis,Kurrle Nina,Maier Anna-Maria,Mohr Sebastian,Schütte Judith,Vassen Lothar,Greve Gabriele,Schulz-Fincke Johannes,Schmitt Martin,Tosic Milica,Metzger Eric,Bug Gesine,Khandanpour Cyrus^ORCID,Wagner Sebastian A.,Lübbert Michael,Jung Manfred,Serve Hubert,Schüle Roland,Berg Tobias

Funder

Deutsche Forschungsgemeinschaft

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/s41375-018-0375-7.pdf

Reference53 articles.

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2. Schenk T, Chen WC, Gollner S, Howell L, Jin L, Hebestreit K, et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med. 2012;18:605–11.

3. Mohammad HP, Smitheman KN, Kamat CD, Soong D, Federowicz KE, Van Aller GS, et al. A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC. Cancer Cell. 2015;28:57–69.