Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune-Reference-Cited by-同舟云学术

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Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune

Published:2016-05-19 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Sun Weiguang,Chen Xintao,Tong Qingyi,Zhu Hucheng,He Yan,Lei Liang,Xue Yongbo,Yao Guangmin,Luo Zengwei,Wang Jianping,Li Hua,Zhang Yonghui

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep26418.pdf

Reference30 articles.

1. Macfarlane, D. P., Forbes, S. & Walker, B. R. Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome. J. Endocrinol. 197, 189–204 (2008).

2. Chapman, K., Holmes, M. & Seckl, J. 11-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action. Physiol Rev. 93, 1139–1206 (2013).

3. Hamilton, B. S. et al. Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes. Eur. J. Pharmacol. 746, 50–55 (2015).

4. Chan, D. S. et al. Structure-based discovery of natural-product-like TNF-α inhibitors. Angew. Chem. Int. Ed. 49, 2922–2926 (2010).

5. Newman, D. J. & Cragg, G. M. Natural Products as Sources of New Drugs from 1981 to 2014. J. Nat. Prod. doi: 10.1021/acs.jnatprod.5b01055 (2016).

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