Homozygosity mapping in 64 Syrian consanguineous families with non-specific intellectual disability reveals 11 novel loci and high heterogeneity

Author:

Abou Jamra R,Wohlfart Sigrun,Zweier Markus,Uebe Steffen,Priebe Lutz,Ekici Arif,Giesebrecht Susanne,Abboud Ahmad,Al Khateeb Mohammed Ayman,Fakher Mahmoud,Hamdan Saber,Ismael Amina,Muhammad Safia,Nöthen Markus M,Schumacher Johannes,Reis André

Publisher

Springer Science and Business Media LLC

Subject

Genetics(clinical),Genetics

Reference29 articles.

1. Ropers HH : Genetics of early onset cognitive impairment. Annu Rev Genomics Hum Genet 2010; 11: 161–187.

2. Rauch A, Hoyer J, Guth S et al: Diagnostic yield of various genetic approaches in patients with unexplained developmental delay or mental retardation. Am J Med Genet A 2006; 140: 2063–2074.

3. Ropers HH, Hamel BC : X-linked mental retardation. Nat Rev Genet 2005; 6: 46–57.

4. Bartley JA, Hall BD : Mental retardation and multiple congenital anomalies of unknown etiology: frequency of occurrence in similarly affected sibs of the proband. Birth Defects Orig Artic Ser 1978; 14: 127–137.

5. Priest JH, Thuline HC, Laveck GD, Jarvis DB : An approach to genetic factors in mental retardation. Studies of families containing at least two siblings admitted to a state institution for the retarded. Am J Ment Defic 1961; 66: 42–50.

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