Dying cells actively regulate adaptive immune responses

Author:

Yatim Nader,Cullen Sean,Albert Matthew L.

Publisher

Springer Science and Business Media LLC

Subject

Energy Engineering and Power Technology,Fuel Technology

Reference178 articles.

1. Steinman, R. M. & Hemmi, H. Dendritic cells: translating innate to adaptive immunity. Curr. Top. Microbiol. Immunol. 311, 17–58 (2006).

2. Bevan, M. J. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J. Exp. Med. 143, 1283–1288 (1976).

3. Bevan, M. J. Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming. J. Immunol. 117, 2233–2238 (1976). In references 2 and 3, Michael Bevan is the first to suggest and experimentally demonstrate the ability to induce a cytotoxic T cell response specific to exogenous antigen, thereby introducing the biological process of cross-priming.

4. Suto, R. & Srivastava, P. K. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269, 1585–1588 (1995).

5. Basu, S. & Srivastava, P. K. Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity. J. Exp. Med. 189, 797–802 (1999). References 4 and 5 are the first to suggest that chaperone proteins such as HSPs and calreticulin have the ability to deliver antigens from an exogenous source into the cross-presentation pathway, and that this has implications for tumour immunity.

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