Affinity maturation of CRISPR-engineered B cell receptors in vivo
Author:
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases
U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41551-024-01184-9.pdf
Reference5 articles.
1. Rogers, G. L. & Cannon, P. M. Genome edited B cells: a new frontier in immune cell therapies. Molecul. Therapy 29, 3192–3204 (2021). A review article that describes B cell editing approaches and their applications.
2. Hartweger, H. et al. HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells. J. Exp. Med. 216, 1301–1310 (2019). One example of an intron-editing approach that introduced antibody heavy and light chains into the immunoglobulin heavy chain (IgH) intron locus.
3. Yin, Y. et al. In vitro affinity maturation of broader and more-potent variants of the HIV-1-neutralizing antibody CAP256-VRC26.25. Proc. Natl Acad. Sci. USA 118, e2106203118 (2021). Applied CRISPR editing to create a library of antibody variants in a B cell line for subsequent selection.
4. He, W. et al. Heavy-chain CDR3-engineered B cells facilitate in vivo evaluation of HIV-1 vaccine candidates. Immunity 58, 2408–2424 (2023). A B cell engineering approach used to generate mice that emulate key features of human B cells for vaccine studies.
5. Voss, J. E. et al. Reprogramming the antigen specificity of B cells using genome-editing technologies. eLife 8, e42995 (2019). A pioneering paper in B cell engineering techniques that introduced a heavy-chain gene into human B cells with two CRISPR–Cas9 cuts.
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