Integrin-linked kinase: a cancer therapeutic target unique among its ILK-Reference-Cited by-同舟云学术

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Integrin-linked kinase: a cancer therapeutic target unique among its ILK

Published:2005-01 Issue:1 Volume:5 Page:51-63
ISSN:1474-175X
Container-title:Nature Reviews Cancer
language:en
Short-container-title:Nat Rev Cancer

Author:

Hannigan Gregory,Troussard Armelle A.,Dedhar Shoukat

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Environmental Science

Link

http://www.nature.com/articles/nrc1524.pdf

Reference133 articles.

1. Hannigan, G. E. et al. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase. Nature 379, 91–96 (1996). First report of the identification of ILK. Demonstration of an interaction with β1-integrin cytoplasmic domain and function in the regulation of anchorage-dependent growth of epithelial cells.

2. Zervas, C. G., Gregory, S. L. & Brown, N. H. Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane. J. Cell Biol. 152, 1007–1018 (2001).

3. Mackinnon, A. C., Qadota, H., Norman, K. R., Moerman, D. G. & Williams, B. D. C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes. Curr. Biol. 12, 787–797 (2002). References 2 and 3 provide genetic evidence in model oganisms for the integrin–ILK connection and show conserved evolutionary function of ILK.

4. Sakai, T. et al. Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 17, 926–940 (2003).

5. Brakebusch, C. & Fassler, R. The integrin-actin connection, an eternal love affair. EMBO J. 22, 2324–2333 (2003).

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