15-Deoxy-Δ12,14-prostaglandin J2 stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue

Author:

Kim D-H,Kim E-H,Na H-K,Sun Y,Surh Y-J

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Reference81 articles.

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2. Asher G, Shaul Y . (2006). Ubiquitin-independent degradation: lessons from the p53 model. Isr Med Assoc J 8: 229–232.

3. Atsmon J, Freeman ML, Meredith MJ, Sweetman BJ, Roberts 2nd LJ . (1990). Conjugation of 9-deoxy-Δ9,12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion. Cancer Res 50: 1879–1885.

4. Azuma Y, Watanabe K, Date M, Daito M, Ohura K . (2004). Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Δ12,14-prostaglandin J2 and the precursors in leukemia cell line THP-1. J Pharmacol Sci 94: 261–270.

5. Barak Y, Juven T, Haffner R, Oren M . (1993). Mdm2 expression is induced by wild type p53 activity. EMBO J 12: 461–468.

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