Protein kinase Cɛ mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2)-Reference-Cited by-同舟云学术

Protein kinase Cɛ mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2)

Published:2010-03-15 Issue:21 Volume:29 Page:3100-3109
ISSN:0950-9232
Container-title:Oncogene
language:en
Short-container-title:Oncogene

Author:

Aziz M H,Hafeez B B,Sand J M,Pierce D B,Aziz S W,Dreckschmidt N E,Verma A K

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Link

http://www.nature.com/articles/onc201063.pdf

Reference43 articles.

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2. Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA . (2005). Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res 65: 5054–5062.

3. Aziz MH, Manoharan HT, Church DR, Dreckschmidt NE, Zhong W, Oberley TD et al. (2007a). Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. Cancer Res 67: 8828–8838.

4. Aziz MH, Manoharan HT, Sand JM, Verma AK . (2007b). Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer. Mol Carcinog 46: 646–653.

5. Aziz MH, Manoharan HT, Verma AK . (2007c). Protein kinase C epsilon, which sensitizes skin to un's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res 67: 1385–1394.

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