CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells-Reference-Cited by-同舟云学术

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CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells

Published:2010-08-23 Issue:47 Volume:29 Page:6257-6266
ISSN:0950-9232
Container-title:Oncogene
language:en
Short-container-title:Oncogene

Author:

Chen K-F,Liu C-Y,Lin Y-C,Yu H-C,Liu T-H,Hou D-R,Chen P-J,Cheng A-L

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Link

http://www.nature.com/articles/onc2010357.pdf

Reference24 articles.

1. Bielinski VA, Mumby MC . (2007). Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Exp Cell Res 313: 3117–3126.

2. Chen KF, Yeh PY, Hsu C, Hsu CH, Lu YS, Hsieh HP et al. (2009a). Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 284: 11121–11133.

3. Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL . (2008). Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res 68: 6698–6707.

4. Chen KF, Yu HC, Liu TH, Lee SS, Chen PJ, Cheng AL . (2009b). Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation. J Hepatol 52: 88–95.

5. Come C, Laine A, Chanrion M, Edgren H, Mattila E, Liu X et al. (2009). CIP2A is associated with human breast cancer aggressivity. Clin Cancer Res 15: 5092–5100.

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