Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway-Reference-Cited by-同舟云学术

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Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

Published:2014-09-09 Issue:1 Volume:5 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Yuan Shuguang,Filipek Slawomir,Palczewski Krzysztof,Vogel Horst

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms5733.pdf

Reference56 articles.

1. Freier, E., Wolf, S. & Gerwert, K. Proton transfer via a transient linear water-molecule chain in a membrane protein. Proc. Natl Acad. Sci. USA 108, 11435–11439 (2011).

2. Venkatakrishnan, A. J. et al. Molecular signatures of G-protein-coupled receptors. Nature 494, 185–194 (2013).

3. Jastrzebska, B., Palczewski, K. & Golczak, M. Role of bulk water in hydrolysis of the rhodopsin chromophore. J. Biol. Chem. 286, 18930–18937 (2011).

4. Angel, T. E., Chance, M. R. & Palczewski, K. Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc. Natl Acad. Sci. USA 106, 8555–8560 (2009).

5. Rasmussen, S. G. F. et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature 477, 549–555 (2011).

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