The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis-Reference-Cited by-同舟云学术

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

Published:1999-09 Issue:9 Volume:5 Page:1071-1075
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Lamlum Hanan,Ilyas Mohammad,Rowan Andrew,Clark Susan,Johnson Victoria,Bell Jennie,Frayling Ian,Efstathiou Jason,Pack Kevin,Payne Stewart,Roylance Rebecca,Gorman Patricia,Sheer Denise,Neale Kay,Phillips Robin,Talbot Ian,Bodmer Walter,Tomlinson Ian

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm0999_1071.pdf

Reference25 articles.

1. Miyaki, M., Tanaka, K., Kikuchi-Yanoshita, R., Muraoka, M. & Konishi, M. Familial polyposis: recent advances. Crit. Rev. Oncol. Hematol. 19,1– 31 (1995).

2. Spirio, L. et al. Alleles of the APC gene: an attenuated form of familial polyposis. Cell 75, 951–957 (1993).

3. Friedl, W. et al. Attenuated familial adenomatous polyposis due to a mutation in the 3´ part of the APC gene. A clue for understanding the function of the APC protein. Hum. Genet. 97, 579– 584 (1996).

4. Hodgson, S.V. et al. Two cases of 5q deletions in patients with familial adenomatous polyposis: possible link with Caroli's disease. J. Med. Genet. 30, 369–375 (1993).

5. Laken, S.J. et al. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nature. Genet. 17, 79– 83 (1997).

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