Negative selection — clearing out the bad apples from the T-cell repertoire
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Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri1085.pdf
Reference95 articles.
1. Petrie, H. T. Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production. Immunol. Rev. 189, 8–20 (2002). A good review of thymic anatomy and the dynamics of T-cell production.
2. Fehling, H. J., Krotkova, A., Saint-Ruf, C. & von Boehmer, H. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 375, 795–798 (1995).
3. Irving, B. A., Alt, F. W. & Killeen, N. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 280, 905–908 (1998).
4. Starr, T. K., Jameson, S. C. & Hogquist, K. A. Positive and negative T cell selection. Annu. Rev. Immunol. 21, 139–176 (2003). This is a clear and comprehensive review of positive and negative selection.
5. Sprent, J. & Kishimoto, H. The thymus and central tolerance. Philos. Trans. R. Soc. Lond. B.Biol. Sci. 356, 609–616 (2001). This review of negative selection places many controversial issues into perspective.
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