Chondroitin sulfate — CONCEPT clear, uncertainties unchanged
Author:
Publisher
Springer Science and Business Media LLC
Subject
Rheumatology
Link
http://www.nature.com/articles/nrrheum.2017.131.pdf
Reference9 articles.
1. Reginster, J., Dudler, J., Blicharski, T. & Pavelka, K. Pharmaceutical-grade chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT). Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2016-210860 (2017).
2. Reginster, J. -Y. et al. Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: expert consensus statement. Osteoarthritis Cartilage 23, 2086–2093 (2015).
3. Roman-Blas, J. A., Castañeda, S., Sánchez-Pernaute, O., Largo, R. & Herrero-Beaumont, G. Combined treatment with chondroitin sulfate and glucosamine sulfate shows no superiority over placebo for reduction of joint pain and functional impairment in patients with knee osteoarthritis. Arthritis Rheumatol. 69, 77–85 (2017).
4. Loken, E. & Gelman, A. Measurement error and the replication crisis. Science 355, 584–585 (2017).
5. Da Costa, B. R. et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet http://dx.doi.org/10.1016/S0140-6736(17)31744-0 (2017).
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