Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum

Author:

Velasco Javier,Luis Adrio José,Ángel Moreno Miguel,Díez Bruno,Soler Gloria,Luis Barredo José

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference36 articles.

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2. Samson, S.M. et al. Cloning and expression of the fungal expandase\hydroxylase gene involved in cephalosporin biosynthesis. Bio/Technology 5, 1207–1214 (1987).

3. Cantwell, C.A., Beckmann, R., Whiteman, P., Queener, S.W. & Abraham, E.P. Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway. Proc. R. Soc. London B 248, 283–289 (1992).

4. Beckman, R., Cantwell, C.A., Whiteman, P., Queener, S.W. & Abraham, E.P. Production of deacetoxycephalosporin C by transformants of Penicillium chrysogenum: Antibiotic biosynthetic pathway engineering. In Industrial microorganisms: basic and applied molecular genetics. (eds Baltz, R.H., Hegeman, G.D. & Skatrud, P.L.) 177–182 (American Society for Microbiology, Washington, DC; 1993).

5. Cantwell, C.A. et al. Cloning and expression of a hybrid Streptomyces clavuligerus cefE gene in Penicillium chrysogenum. Curr. Genet. 17, 213–221 (1990).

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