Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs
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Published:2020-11
Issue:11
Volume:26
Page:1788-1800
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Schneider Jay W.ORCID, Oommen SajiORCID, Qureshi Muhammad Y.ORCID, Goetsch Sean C., Pease David R.ORCID, Sundsbak Rhianna S., Guo WeiORCID, Sun MingmingORCID, Sun HanORCID, Kuroyanagi Hidehito, Webster Dennis A., Coutts Alexander W., Holst Kimberly A., Edwards Brooks S., Newville Nikolas, Hathcock Matthew A., Melkamu Tamene, Briganti FrancescaORCID, Wei WuORCID, Romanelli Maria G.ORCID, Fahrenkrug Scott C., Frantz Doug E.ORCID, Olson Timothy M., Steinmetz Lars M.ORCID, Carlson Daniel F.ORCID, Nelson Timothy J., Peral Susana Cantero, Edgerton Sarah, Wobig Joan, Rasmussen Boyd, Scholz Jodi A., Cetta Frank, Suddendorf Scott H., Pedersen Joanne M., Krage Steve, Frisk Craig S., Reece Chelsea L., Miller Angela R., Martineau Sara E., Johnson Rebecca K., Breuer Amanda L., Fox Janell K.,
Funder
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases American Heart Association
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference49 articles.
1. Brauch, K. M. et al. Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy. J. Am. Coll. Cardiol. 54, 930–941 (2009). 2. Li, S., Guo, W., Dewey, C. N. & Greaser, M. L. Rbm20 regulates titin alternative splicing as a splicing repressor. Nucleic Acids Res. 41, 2659–2672 (2013). 3. Watanabe, T., Kimura, A. & Kuroyanagi, H. Alternative splicing regulator RBM20 and cardiomyopathy. Front. Mol. Biosci. 5, 105 (2018). 4. Murayama, R. et al. Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-binding motif protein 20 (RBM20) through nuclear localization. Sci. Rep. 8, 8970 (2018). 5. Filippello, A., Lorenzi, P., Bergamo, E. & Romanelli, M. G. Identification of nuclear retention domains in the RBM20 protein. FEBS Lett. 587, 2989–2995 (2013).
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