Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort-Reference-Cited by-同舟云学术

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Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort

Published:2021-05-27 Issue:6 Volume:27 Page:1088-1096
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Wade Kaitlin H.,Lam Brian Y. H.^ORCID,Melvin Audrey,Pan Warren,Corbin Laura J.^ORCID,Hughes David A.^ORCID,Rainbow Kara,Chen Jian-Hua,Duckett Katie,Liu Xiaoming,Mokrosiński Jacek^ORCID,Mörseburg Alexander,Neaves Sam,Williamson Alice,Zhang Chen,Farooqi I. Sadaf,Yeo Giles S. H.^ORCID,Timpson Nicholas J.^ORCID,O’Rahilly Stephen^ORCID

Funder

Wellcome Trust

RCUK | Medical Research Council

RCUK | Biotechnology and Biological Sciences Research Council

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/s41591-021-01349-y.pdf

Reference43 articles.

1. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994).

2. Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131–141 (1997).

3. Montague, C. T. et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903–908 (1997).

4. Yeo, G. S. et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat. Genet. 20, 111–112 (1998).

5. Clément, K. et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398–401 (1998).

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