Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae

Author:

Ernst Christoph M.ORCID,Braxton Julian R.ORCID,Rodriguez-Osorio Carlos A.ORCID,Zagieboylo Anna P.,Li Li,Pironti AlejandroORCID,Manson Abigail L.,Nair Anil V.,Benson Maura,Cummins Kaelyn,Clatworthy Anne E.,Earl Ashlee M.ORCID,Cosimi Lisa A.,Hung Deborah T.ORCID

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Anita and Josh Bekenstein Gift

Deutsche Forschungsgemeinschaft

Massachusetts General Hospital - Fund for Medical Discovery

Mexican National Council for Science and Technology (CONACYT) and The Fundacion Mexico en Harvard

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference64 articles.

1. Antibiotic Resistance Threats in the United States (Centers for Disease Control and Prevention, 2013).

2. Rapid Risk Assessment: Carbapenem-resistant Enterobacteriaceae—First update (European Centre for Disease Prevention and Control, 2018).

3. Pitout, J. D., Nordmann, P. & Poirel, L. Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. Antimicrob. Agents Chemother. 59, 5873–5884 (2015).

4. Antimicrobial Resistance—Global Report on Surveillance (World Health Organization, 2014).

5. Deleo, F. R. et al. Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. Proc. Natl Acad. Sci. USA 111, 4988–4993 (2014).

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