Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps-Reference-Cited by-同舟云学术

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps

Published:2021-11 Issue:11 Volume:27 Page:1876-1884
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

,Adeyemo Adebowale,Balaconis Mary K.,Darnes Deanna R.,Fatumo Segun,Granados Moreno Palmira,Hodonsky Chani J.,Inouye Michael^ORCID,Kanai Masahiro,Kato Kazuto,Knoppers Bartha M.,Lewis Anna C. F.,Martin Alicia R.,McCarthy Mark I.,Meyer Michelle N.,Okada Yukinori,Richards J. Brent,Richter Lucas,Ripatti Samuli,Rotimi Charles N.,Sanderson Saskia C.,Sturm Amy C.,Verdugo Ricardo A.,Widen Elisabeth,Willer Cristen J.,Wojcik Genevieve L.,Zhou Alicia

Funder

British Heart Foundation

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.nature.com/articles/s41591-021-01549-6.pdf

Reference104 articles.

1. Torkamani, A., Wineinger, N. E. & Topol, E. J. The personal and clinical utility of polygenic risk scores. Nat. Rev. Genet. 19, 581–590 (2018).

2. Ganna, A. et al. Multilocus genetic risk scores for coronary heart disease prediction. Arter. Thromb. Vasc. Biol. 33, 2267–2272 (2013).

3. Abraham, G. et al. Genomic prediction of coronary heart disease. Eur. Heart J. 37, 3267–3278 (2016).