Datopotamab–deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial
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Published:2024-09-14
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Volume:
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Shatsky Rebecca A., Trivedi Meghna S., Yau Christina, Nanda RitaORCID, Rugo Hope S.ORCID, Davidian Marie, Tsiatis Butch, Wallace Anne M., Chien A. Jo, Stringer-Reasor Erica, Boughey Judy C.ORCID, Omene Coral, Rozenblit Mariya, Kalinsky KevinORCID, Elias Anthony D., Vaklavas ChristosORCID, Beckwith Heather, Williams Nicole, Arora Mili, Nangia Chaitali, Roussos Torres Evanthia T.ORCID, Thomas Brittani, Albain Kathy S., Clark Amy S., Falkson Carla, Hershman Dawn L., Isaacs ClaudineORCID, Thomas AlexandraORCID, Tseng Jennifer, Sanford Amy, Yeung Kay, Boles Sarah, Chen Yunni Yi, Huppert Laura, Jahan Nusrat, Parker Catherine, Giridhar Karthik, Howard Frederick M., Blackwood M. Michele, Sanft Tara, Li Wen, Onishi NatsukoORCID, Asare Adam L., Beineke Philip, Norwood Peter, Brown-Swigart LamornaORCID, Hirst Gillian L.ORCID, Matthews Jeffrey B., Moore Brian, Symmans W. FraserORCID, Price Elissa, Heditsian Diane, LeStage Barbara, Perlmutter Jane, Pohlmann PaulaORCID, DeMichele AngelaORCID, Yee DouglasORCID, van ’t Veer Laura J.ORCID, Hylton Nola M., Esserman Laura J.ORCID
Funder
U.S. Department of Health & Human Services | National Institutes of Health
Publisher
Springer Science and Business Media LLC
Reference40 articles.
1. Siegel, R. L., Giaquinto, A. N. & Jemal, A. Cancer statistics, 2024. CA Cancer J. Clin. 74, 12–49 (2024). 2. Giaquinto, A. N. et al. Breast cancer Statistics, 2022. CA Cancer J. Clin. 72, 524–541 (2022). 3. Swain, S. M., Whaley, F. S. & Ewer, M. S. Congestive heart failure in patients treated with doxorubicin. Cancer 97, 2869–2879 (2003). 4. Harrington, D. & Parmigiani, G. I-SPY 2—a glimpse of the future of phase 2 drug development? N. Engl. J. Med. 375, 7–9 (2016). 5. Das, S. & Lo, A. W. Re-inventing drug development: a case study of the I-SPY 2 breast cancer clinical trials program. Contemp. Clin. Trials 62, 168–174 (2017).
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