Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial
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Published:2022-04-11
Issue:5
Volume:28
Page:1022-1030
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Casazza Joseph P.ORCID, Cale Evan M., Narpala Sandeep, Yamshchikov Galina V., Coates Emily E., Hendel Cynthia S., Novik Laura, Holman LaSonji A., Widge Alicia T.ORCID, Apte Preeti, Gordon Ingelise, Gaudinski Martin R., Conan-Cibotti Michelle, Lin Bob C., Nason Martha C., Trofymenko Olga, Telscher Shinyi, Plummer Sarah H., Wycuff Diane, Adams William C., Pandey Janardan P., McDermott AdrianORCID, Roederer Mario, Sukienik Avery N., O’Dell Sijy, Gall Jason G., Flach Britta, Terry Travis L., Choe Misook, Shi Wei, Chen XuejunORCID, Kaltovich Florence, Saunders Kevin O.ORCID, Stein Judy A., Doria-Rose Nicole A., Schwartz Richard M., Balazs Alejandro B.ORCID, Baltimore DavidORCID, Nabel Gary J.ORCID, Koup Richard A., Graham Barney S., Ledgerwood Julie E., Mascola John R., Andrews Charla, Arthur Anita, Awan Seemal F., Beck Allison, Burch Eugeania, Burgos Florez Maria C., Berkowitz Nina M., Boritz Eli A., Carlton Kevin, Cartagena Cora T., Carter Christina, Chen Grace L., Costner Pamela, Cunningham Jennifer, Douek Daniel C., Eshun Aba M., Evans Catina, Hicks Renunda, Houser Katherine V., Jones Justine, Larkin Brenda, Le Lam, Mendoza Floreliz, Migueles Stephen, Misasi John, Nguyen Thuy A., Ola Abidemi, Parker Karen, Pittman Iris, Requilman La’ Shawn, Rothwell Ro Shauna, Schieber Gretchen L., Saunders Jamie, Sitar Sandra, Tran Colin, Trofymenko Olga, Vasilenko Olga, Waheed Sana, Wang Lingshu, Wang Xiaolin, Whalen William, Williams Pernell, Wu Richard L., Zephir Kathy,
Funder
Division of Intramural Research, National Institute of Allergy and Infectious Diseases Leidos Biomedical Research, Inc MGH Transformative Scholars Program U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse Charles H. Hood Foundation
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference69 articles.
1. Fuchs, S. P. & Desrosiers, R. C. Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies. Mol. Ther. Methods Clin. Dev. 3, 16068 (2016). 2. Rerks-Ngarm, S. et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N. Engl. J. Med. 361, 2209–2220 (2009). 3. Gift, S. K., Leaman, D. P., Zhang, L., Kim, A. S. & Zwick, M. B. Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex. J. Virol. 91, e01216–17 (2017). 4. Torrents de la Pena, A. et al. Improving the immunogenicity of native-like HIV-1 envelope trimers by hyperstabilization. Cell Rep. 20, 1805–1817 (2017). 5. Klein, J. S. & Bjorkman, P. J. Few and far between: how HIV may be evading antibody avidity. PLoS Pathog. 6, e1000908 (2010).
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