Identification of genetic correlates of coronary artery disease in diverse ancestral populations
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
https://www.nature.com/articles/s41591-022-01915-y.pdf
Reference5 articles.
1. van der Harst, P. & Verweij, N. Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease. Circ. Res. 122, 433–443 (2018). This paper represents the largest published GWAS of CAD so far, with the vast majority of participants studied being of European ancestry.
2. Coronary Artery Disease (C4D) Genetics Consortium. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat. Genet. 43, 339–344 (2011). This paper reports the largest GWAS of CAD among a South Asian population and demonstrates high concordance with findings in European populations.
3. Koyama, S. et al. Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease. Nat. Genet. 52, 1169–1177 (2020). This paper reports the largest GWAS of CAD among people of East Asian ancestry so far and demonstrates high concordance with findings in European populations.
4. Clarke, S. L., Assimes, T. L. & Tcheandjieu, C. The propagation of racial disparities in cardiovascular genomics research. Circ. Genom. Precis. Med. 14, e003178 (2021). This review summarizes the disparities in cardiovascular genomics research so far, including CAD.
5. Graham, S. E. et al. The power of genetic diversity in genome-wide association studies of lipids. Nature 600, 675–679 (2021). This paper shows how the study of diverse populations improves the understanding of the biology of blood lipid levels, as well as the ability to predict the levels of ‘bad’ cholesterol.
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