A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy
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Published:2023-03-13
Issue:4
Volume:29
Page:906-916
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Stein-Thoeringer Christoph K., Saini Neeraj Y., Zamir EliORCID, Blumenberg ViktoriaORCID, Schubert Maria-Luisa, Mor UriaORCID, Fante Matthias A., Schmidt Sabine, Hayase Eiko, Hayase Tomo, Rohrbach RomanORCID, Chang Chia-Chi, McDaniel Lauren, Flores Ivonne, Gaiser Rogier, Edinger Matthias, Wolff DanielORCID, Heidenreich Martin, Strati Paolo, Nair Ranjit, Chihara Dai, Fayad Luis E., Ahmed Sairah, Iyer Swaminathan P., Steiner Raphael E.ORCID, Jain PreeteshORCID, Nastoupil Loretta J.ORCID, Westin JasonORCID, Arora Reetakshi, Wang Michael L.ORCID, Turner Joel, Menges Meghan, Hidalgo-Vargas Melanie, Reid Kayla, Dreger Peter, Schmitt Anita, Müller-Tidow CarstenORCID, Locke Frederick L.ORCID, Davila Marco L., Champlin Richard E., Flowers Christopher R., Shpall Elizabeth J., Poeck Hendrik, Neelapu Sattva S.ORCID, Schmitt MichaelORCID, Subklewe Marion, Jain Michael D.ORCID, Jenq Robert R.ORCID, Elinav EranORCID
Funder
Mark Foundation Endeavor Award
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference50 articles.
1. Gopalakrishnan, V. et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359, 97–103 (2018). 2. Routy, B. et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 359, 91–97 (2018). 3. Matson, V. et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science 359, 104–108 (2018). 4. Peled, J. U. et al. Intestinal microbiota and relapse after hematopoietic-cell transplantation. J. Clin. Oncol. 35, 1650–1659 (2017). 5. Stein-Thoeringer, C. K. et al. Lactose drives Enterococcus expansion to promote graft-versus-host disease. Science 366, 1143–1149 (2019).
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