Genetic risk factors have a substantial impact on healthy life years-Reference-Cited by-同舟云学术

Genetic risk factors have a substantial impact on healthy life years

Published:2022-09 Issue:9 Volume:28 Page:1893-1901
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Jukarainen Sakari^ORCID,Kiiskinen Tuomo^ORCID,Kuitunen Sara,Havulinna Aki S.,Karjalainen Juha,Cordioli Mattia^ORCID,Rämö Joel T.^ORCID,Mars Nina,Samocha Kaitlin E.,Ollila Hanna M.,Pirinen Matti^ORCID,Ganna Andrea^ORCID,

Abstract

AbstractThe impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genetic information from 735,748 individuals and consider 80 diseases. Rare variants had the highest effect on DALYs at the individual level. Among common variants, rs3798220 (LPA) had the strongest individual-level effect, with 1.18 DALYs from carrying 1 versus 0 copies. Being in the top 10% versus the bottom 90% of a polygenic score for multisite chronic pain had an effect of 3.63 DALYs. Some common variants had a population-level effect comparable to modifiable risk factors such as high sodium intake and low physical activity. Attributable DALYs vary between males and females for some genetic exposures. Genetic risk factors can explain a sizable number of healthy life years lost both at the individual and population level.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.nature.com/articles/s41591-022-01957-2.pdf

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