Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
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Published:2020-08-03
Issue:10
Volume:26
Page:1549-1556
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Bernard ElsaORCID, Nannya Yasuhito, Hasserjian Robert P., Devlin Sean M., Tuechler HeinzORCID, Medina-Martinez Juan S., Yoshizato TetsuichiORCID, Shiozawa Yusuke, Saiki Ryunosuke, Malcovati Luca, Levine Max F.ORCID, Arango Juan E., Zhou Yangyu, Solé Francesc, Cargo Catherine A., Haase Detlef, Creignou Maria, Germing Ulrich, Zhang Yanming, Gundem Gunes, Sarian Araxe, van de Loosdrecht Arjan A., Jädersten Martin, Tobiasson Magnus, Kosmider Olivier, Follo Matilde Y.ORCID, Thol Felicitas, Pinheiro Ronald F., Santini Valeria, Kotsianidis Ioannis, Boultwood JacquelineORCID, Santos Fabio P. S., Schanz Julie, Kasahara Senji, Ishikawa Takayuki, Tsurumi Hisashi, Takaori-Kondo AkifumiORCID, Kiguchi Toru, Polprasert Chantana, Bennett John M., Klimek Virginia M., Savona Michael R.ORCID, Belickova MonikaORCID, Ganster ChristinaORCID, Palomo Laura, Sanz GuillermoORCID, Ades Lionel, Della Porta Matteo Giovanni, Elias Harold K., Smith Alexandra G., Werner Yesenia, Patel Minal, Viale Agnès, Vanness Katelynd, Neuberg Donna S.ORCID, Stevenson Kristen E., Menghrajani Kamal, Bolton Kelly L., Fenaux Pierre, Pellagatti Andrea, Platzbecker Uwe, Heuser MichaelORCID, Valent Peter, Chiba Shigeru, Miyazaki Yasushi, Finelli Carlo, Voso Maria TeresaORCID, Shih Lee-Yung, Fontenay MichaelaORCID, Jansen Joop H., Cervera José, Atsuta Yoshiko, Gattermann Norbert, Ebert Benjamin L.ORCID, Bejar RafaelORCID, Greenberg Peter L., Cazzola MarioORCID, Hellström-Lindberg Eva, Ogawa SeishiORCID, Papaemmanuil ElliORCID
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference49 articles.
1. Kandoth, C. et al. Mutational landscape and significance across 12 major cancer types. Nature 502, 333–339 (2013). 2. Zehir, A. et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat. Med. 23, 703–713 (2017). 3. Haase, D. et al. TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups. Leukemia 33, 1747–1758 (2019). 4. Bejar, R. et al. Clinical effect of point mutations in myelodysplastic syndromes. N. Engl. J. Med. 364, 2496–2506 (2011). 5. Kitagawa, M., Yoshida, S., Kuwata, T., Tanizawa, T. & Kamiyama, R. p53 expression in myeloid cells of myelodysplastic syndromes. Association with evolution of overt leukemia. Am. J. Pathol. 145, 338–344 (1994).
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