Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
https://www.nature.com/articles/s41591-022-02198-z.pdf
Reference5 articles.
1. Kumar, S. K. et al. Multiple myeloma. Nat. Rev. Dis. Primers 3, 17046 (2017). A review article that accurately summarizes the biology, genetics and therapeutics of MM.
2. Dhodapkar, M. MGUS to myeloma: a mysterious gammopathy of underexplored significance. Blood 128, 2599–2606 (2016). A comprehensive review focused on how precursor states evolve into clinically evident myeloma.
3. Mateos, M.-V. et al. Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma. N. Engl. J. Med. 369, 438–447 (2013). An article reporting the first clinical trial that demonstrated clinical benefit of early immunotherapy in smoldering MM.
4. Chesi, M. et al. AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell 13, 167–180 (2008). A landmark paper reporting a mouse model driven by a single genetic lesion in the Myc oncogene, which develops MM at a very late age.
5. Zavidij, O. et al. Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma. Nat. Cancer 1, 493–506 (2020). A description of the composition of the BM immune microenvironment in patients with plasma cell malignancies using single-cell approaches.
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