Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses
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Published:2020-12-17
Issue:2
Volume:27
Page:279-288
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Barrett Jordan R.ORCID, Belij-Rammerstorfer Sandra, Dold Christina, Ewer Katie J.ORCID, Folegatti Pedro M.ORCID, Gilbride Ciaran, Halkerston Rachel, Hill Jennifer, Jenkin DanielORCID, Stockdale LisaORCID, Verheul Marije K., Aley Parvinder K., Angus BrianORCID, Bellamy Duncan, Berrie Eleanor, Bibi Sagida, Bittaye Mustapha, Carroll Miles W., Cavell Breeze, Clutterbuck Elizabeth A., Edwards NickORCID, Flaxman Amy, Fuskova MichelleORCID, Gorringe AndrewORCID, Hallis Bassam, Kerridge Simon, Lawrie Alison M., Linder Aline, Liu Xinxue, Madhavan Meera, Makinson Rebecca, Mellors Jack, Minassian AngelaORCID, Moore Maria, Mujadidi YamaORCID, Plested Emma, Poulton IanORCID, Ramasamy Maheshi N.ORCID, Robinson Hannah, Rollier Christine S.ORCID, Song RinnORCID, Snape Matthew D., Tarrant Richard, Taylor StephenORCID, Thomas Kelly M.ORCID, Voysey Merryn, Watson Marion E. E.ORCID, Wright DanielORCID, Douglas Alexander D.ORCID, Green Catherine M., Hill Adrian V. S.ORCID, Lambe TeresaORCID, Gilbert SarahORCID, Pollard Andrew J.ORCID, Aboagye Jeremy, Alderson Jennifer, Ali Aabidah, Allen Elizabeth, Allen Lauren, Anslow Rachel, Arancibia-Cárcamo Carolina V., Arbe-Barnes Edward H., Baker Megan, Baker Philip, Baker Natalie, Baleanu Ioana, Barnes Eleanor, Bates Louise, Batten Alexander, Beadon Kirsten, Beckley Rebecca, Beveridge Amy, Bewley Kevin R., Bijker Else Margreet, Blackwell Luke, Blundell Caitlin L., Bolam Emma, Boland Elena, Borthwick Nicola, Boyd Amy, Brenner Tanja, Brown Philip, Brown-O’Sullivan Charlie, Brunt Emily, Burbage Jamie, Buttigieg Karen R., Byard Nicholas, Cabrera Puig Ingrid, Camara Susana, Cao Michelangelo, Cappuccini Federica, Carr Melanie, Carroll Miles W., Chadwick Jim, Chelysheva Irina, Cho Jee-Sun, Cifuentes Liliana, Clark Elizabeth, Colin-Jones Rachel, Conlon Christopher P., Coombes Naomi S., Cooper Rachel, Crocker Wendy E. M., Cunningham Christina J., Damratoski Brad E., Datoo Mehreen S., Datta Chandrabali, Davies Hannah, Demissie Tesfaye, Di Maso Claudio, DiTirro Danielle, Dong Tao, Donnellan Francesca R., Douglas Naomi, Downing Charlotte, Drake Jonathan, Drake-Brockman Rachael, Drury Ruth Elizabeth, Dunachie Susanna Jane, Muhanna Omar El, Elias Sean C., Elmore Michael J., Emary Katherine R. W., English Marcus Rex, Felle Sally, Feng Shuo, Da Silva Carla Ferreira, Field Samantha, Fisher Richard, Ford Karen J., Fowler Jamie, Francis Emma, Frater John, Furze Julie, Galian-Rubio Pablo, Garlant Harriet, Godwin Kerry, Gorini Giacomo, Gracie Lara, Gupta Gaurav, Hamilton Elizabeth, Hamlyn Joseph, Hanumunthadu Brama, Harris Stephanie A., Harrison Daisy, Hart Thomas C., Hawkins Sophia, Henry John Aaron, Hodges Gina, Hodgson Susanne H. C., Hou Mimi M., Howe Elizabeth, Howell Nicola, Huang Ben, Humphries Holly, Iveson Poppy, Jackson Susan, Jackson Frederic, Jauregui Sam, Jeffery Katie, Jones Elizabeth, Jones Kathryn, Kailath Reshma, Keen Jade, Kelly Sarah, Kelly Dearbhla, Kelly Elizabeth, Kerr David, Khan Liaquat, Khozoee Baktash, Killen Annabel, Kinch Jasmin, King Thomas B., King Lloyd, Kingham-Page Lucy, Klenerman Paul, Knight Julian C., Knott Daniel, Koleva Stanislava, Larkworthy Colin W., Larwood Jessica P. J., Lees Emily A., Lelliott Alice, Leung Stephanie, Li Yuanyuan, Lias Amelia M., Lipworth Samuel, Liu Shuchang, Loew Lisa, Lopez Ramon Raquel, Mallett Garry, Mansatta Kushal, Marchevsky Natalie G., Marinou Spyridoula, Marlow Emma, Marshall Julia L., Matthews Philippa, McEwan Joanne, McGlashan Joanna, McInroy Lorna, Meddaugh Gretchen, Mentzer Alexander J., Mirtorabi Neginsadat, Morey Ella, Morgans Roisin, Morris Susan Jane, Morrison Hazel, Morshead Gertraud, Morter Richard, Moya Nathifa, Mukhopadhyay Ekta, Muller Jilly, Munro Claire, Murphy Sarah, Mweu Philomena, Noé Andrés, Nugent Fay L., Nuthall Elizabeth, O’Brien Katie, O’Connor Daniel, O’Donnell Denise, Oguti Blanché, Olchawski Vicki, Oliveria Catarina, O’Reilly Peter John, Osborne Piper, Owino Nelly, Parker Kaye, Parracho Helena, Patrick-Smith Maia, Peng Yanchun, Penn Elizabeth, Peralta Alvarez Marco Polo, Perring James, Petropoulos Christos, Pfafferott Katja, Pipini Dimitra, Phillips Daniel, Proud Pamela, Provstgaard-Morys Samuel, Pulido David, Radia Kajal, Rajapaksa Durga, Ramos Lopez Fernando, Ratcliffe Helen, Rawlinson Thomas, Pabon Emilia Reyes, Rhead Sarah, Ritchie Adam John, Roberts Hannah, Roche Sophie, Rudiansyah Indra, Salvador Stephannie, Sanders Helen, Sanders Katherine, Satti Iman, Schmid Annina, Schofield Ella, Screaton Gavin, Sedik Cynthia, Shaik Imam, Sharpe Hannah R., Shea Adam, Silk Sarah, Silva-Reyes Laura, Skelly Donal T., Smith Catherine C., Smith David J., Spencer Alexandra J., Stafford Elizabeth, Szigeti Anna, Tahiri-Alaoui Abdessamad, Tanner Rachel, Taylor Iona Jennifer, Taylor Keja, te Water Naude Rebecca, Themistocleous Yrene, Themistocleous Andreas, Thomas Merin, Thomas Tonia M., Thompson Amber, Tinh Lan, Tomic Adriana, Tonks Susan, Towner James, Tran Nguyen, Tree Julia A., Truby Adam, Turner Cheryl, Turner Nicola, Ulaszewska Marta, Varughese Rachel, Vichos Iason, Walker Laura, Wand Matthew, White Caroline, White Rachel, Williams Paul, Worth Andrew T., Wrin Terri, Yao Xin Li, Zizi Dalila,
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference55 articles.
1. WHO COVID-19. Draft Landscape of COVID-19 Candidate Vaccines. https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines (2020). 2. Zhu, F. C. et al. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet 396, 479–488 (2020). 3. Logunov, D. Y. et al. Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia. Lancet 396, 887–897 (2020). 4. Jackson, L. A. et al. An mRNA vaccine against SARS-CoV-2—preliminary report. N. Engl. J. Med. https://doi.org/10.1056/nejmoa2022483 (2020). 5. Xia, S. et al. Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: interim analysis of 2 randomized clinical trials. JAMA 324, 951–960 (2020).
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