Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo-Reference-Cited by-同舟云学术

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

Published:2018-07-23 Issue:9 Volume:24 Page:1384-1394
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Madiraju Anila K.,Qiu Yang,Perry Rachel J.,Rahimi Yasmeen,Zhang Xian-Man,Zhang Dongyan,Camporez João-Paulo G.,Cline Gary W.,Butrico Gina M.,Kemp Bruce E.^ORCID,Casals Gregori,Steinberg Gregory R.,Vatner Daniel F.,Petersen Kitt F.,Shulman Gerald I.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/s41591-018-0125-4.pdf

Reference68 articles.

1. Owen, M. R., Doran, E. & Halestrap, A. P. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J. 348, 607–614 (2000).

2. El-Mir, M.-Y. et al. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J. Biol. Chem. 275, 223–228 (2000).

3. He, L. et al. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell 137, 635–646 (2009).

4. Cao, J. et al. Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK). J. Biol. Chem. 289, 20435–20446 (2014).

5. Fullerton, M. D. et al. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat. Med. 19, 1649–1654 (2013).

Cited by 215 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Polysaccharides in Medicinal and Food Homologous Plants regulate intestinal flora to improve type 2 diabetes: Systematic review;Phytomedicine;2024-11

2. Blocking the utilization of carbon sources via two pathways to induce tumor starvation for cancer treatment;Nanomedicine: Nanotechnology, Biology and Medicine;2024-10

3. Anti-echinococcal effect of metformin in advanced experimental cystic echinococcosis: reprogrammed intermediary carbon metabolism in the parasite;Antimicrobial Agents and Chemotherapy;2024-09-12

4. From Hyperinsulinemia to Cancer Progression: How Diminishing Glucose Storage Capacity Fuels Insulin Resistance;Aging and Cancer;2024-08-27

5. Repurposing existing drugs for the treatment ofCOVID-19/SARS-CoV-2: A review of pharmacological effects and mechanism of action;Heliyon;2024-08