A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease-Reference-Cited by-同舟云学术

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A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

Published:2020-03 Issue:3 Volume:26 Page:398-407
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Barthélemy Nicolas R., ,Li Yan,Joseph-Mathurin Nelly,Gordon Brian A.^ORCID,Hassenstab Jason,Benzinger Tammie. L. S.^ORCID,Buckles Virginia,Fagan Anne M.,Perrin Richard J.,Goate Alison M.^ORCID,Morris John C.,Karch Celeste M.^ORCID,Xiong Chengjie,Allegri Ricardo,Mendez Patricio Chrem,Berman Sarah B.,Ikeuchi Takeshi^ORCID,Mori Hiroshi,Shimada Hiroyuki,Shoji Mikio,Suzuki Kazushi,Noble James,Farlow Martin,Chhatwal Jasmeer^ORCID,Graff-Radford Neill R.,Salloway Stephen,Schofield Peter R.^ORCID,Masters Colin L.,Martins Ralph N.,O’Connor Antoinette,Fox Nick C.,Levin Johannes,Jucker Mathias^ORCID,Gabelle Audrey,Lehmann Sylvain,Sato Chihiro,Bateman Randall J.,McDade Eric^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute on Aging

Alzheimer’s Association

Raul Carrea Institute for Neurological Research

Development Grants for Dementia from Japan Agency for Medical Research and Development

RCUK | Medical Research Council

Deutsches Zentrum für Neurodegenerative Erkrankungen

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke

BrightFocus Foundation

Fondation du Plan Alzheimer

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/s41591-020-0781-z.pdf

Reference65 articles.

1. Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D. & Crowther, R. A. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer’s disease. Neuron 3, 519–526 (1989).

2. Grundke-Iqbal, I. et al. Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology. Proc. Natl Acad. Sci. USA 83, 4913–4917 (1986).

3. Kimura, T., Sharma, G., Ishiguro, K. & Hisanaga, S. Phospho-tau bar code: analysis of phosphoisotypes of tau and its application to tauopathy. Front. Neurosci. 12, 44 (2018).

4. Crowther, R. A. Straight and paired helical filaments in Alzheimer disease have a common structural unit. Proc. Natl Acad. Sci. USA 88, 2288–2292 (1991).

5. Fitzpatrick, A. W. P. et al. Cryo-EM structures of tau filaments from Alzheimer’s disease. Nature 547, 185–190 (2017).

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