Network quantification of EGFR signaling unveils potential for targeted combination therapy-Reference-Cited by-同舟云学术

Network quantification of EGFR signaling unveils potential for targeted combination therapy

Published:2013-01 Issue:1 Volume:9 Page:673
ISSN:1744-4292
Container-title:Molecular Systems Biology
language:en
Short-container-title:Mol Syst Biol

Author:

Klinger Bertram¹²,Sieber Anja¹,Fritsche‐Guenther Raphaela¹,Witzel Franziska¹²,Berry Leanne³,Schumacher Dirk¹,Yan Yibing⁴,Durek Pawel¹²⁵,Merchant Mark³,Schäfer Reinhold¹⁵,Sers Christine¹,Blüthgen Nils¹²

Affiliation:

1. Laboratory of Molecular Tumour Pathology, Institute of Pathology, Charité ‐ Universitätsmedizin Berlin Berlin Germany

2. Institute for Theoretical Biology, Humboldt University Berlin Berlin Germany

3. Department of Translation Oncology, Genentech, Inc. South San Francisco CA USA

4. Oncology Biomarker Development, Genentech, Inc. South San Francisco CA USA

5. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg, Germany

Publisher

EMBO

Subject

Applied Mathematics,Computational Theory and Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Information Systems

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1038/msb.2013.29

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4. Inhibition of Ras for cancer treatment: the search continues

5. Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines

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