Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Hematology
Link
http://www.nature.com/articles/bcj201645.pdf
Reference28 articles.
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3. De Luca K, Frances-Duvert V, Asensio MJ, Ihsani R, Debien E, Taillardet M et al. The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fate. Leukemia 2009; 23: 2063–2074.
4. Esplin BL, Shimazu T, Welner RS, Garrett KP, Nie L, Zhang Q et al. Chronic exposure to a TLR ligand injures hematopoietic stem cells. J Immunol 2011; 186: 5367–5375.
5. Zhao Y, Ling F, Wang HC, Sun XH . Chronic TLR signaling impairs the long-term repopulating potential of hematopoietic stem cells of wild type but not Id1 deficient mice. PLoS One 2013; 8: e55552.
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