Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors-Reference-Cited by-同舟云学术

Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Published:2016-11-21 Issue:1 Volume:23 Page:60-68
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Steinhart Zachary,Pavlovic Zvezdan,Chandrashekhar Megha,Hart Traver,Wang Xiaowei,Zhang Xiaoyu,Robitaille Mélanie,Brown Kevin R,Jaksani Sridevi,Overmeer René,Boj Sylvia F,Adams Jarrett,Pan James,Clevers Hans,Sidhu Sachdev,Moffat Jason,Angers Stéphane^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.4219.pdf

Reference36 articles.

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2. Schuijers, J. & Clevers, H. Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. EMBO J. 31, 2685–2696 (2012).

3. Anastas, J.N. & Moon, R.T. WNT signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer 13, 11–26 (2013).

4. Polakis, P. Wnt signaling in cancer. Cold Spring Harb. Perspect. Biol. 4 (2012).

5. Madan, B. & Virshup, D.M. Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs. Mol. Cancer Ther. 14, 1087–1094 (2015).

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