Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota

Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis

Published:2017-05 Issue:5 Volume:7 Page:e1138-e1138
ISSN:2158-3188
Container-title:Translational Psychiatry
language:en
Short-container-title:Transl Psychiatry

Author:

Zhang J-c,Yao W,Dong C,Yang C,Ren Q^ORCID,Ma M,Hashimoto K

Publisher

Springer Science and Business Media LLC

Subject

Biological Psychiatry,Cellular and Molecular Neuroscience,Psychiatry and Mental health

Link

http://www.nature.com/articles/tp2017112.pdf

Reference66 articles.

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3. Miller AH, Maletic V, Raison CL . Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009; 65: 732–741.

4. Raison CL, Lowry CA, Rook GA . Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. Arch Gen Psychiatry 2010; 67: 1211–1224.

5. Hashimoto K . Inflammatory biomarkers as differential predictors of antidepressant response. Int J Mol Sci 2015; 16: 7796–7801.

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