Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation

Author:

George Thompson Alayna M.,Ursu Oleg,Babkin Petr,Iancu Cristina V.,Whang Alex,Oprea Tudor I.,Choe Jun-yong

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference48 articles.

1. Vos, M. B., Kimmons, J. E., Gillespie, C., Welsh, J. & Blanck, H. M. Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey. Medscape J. Med. 10, 160 (2008).

2. Tappy, L. & Lê, K.-A. Metabolic effects of fructose and the worldwide increase in obesity. Physiol. Rev. 90, 23–46 (2010).

3. Hwang, I. S., Ho, H., Hoffman, B. B. & Reaven, G. M. Fructose-induced insulin resistance and hypertension in rats. Hypertension 10, 512–516 (1987).

4. Bremer, A. A., Mietus-Snyder, M. & Lustig, R. H. Toward a unifying hypothesis of metabolic syndrome. Pediatrics 129, 557–570 (2012).

5. Burant, C. F., Takeda, J., Brot-Laroche, E., Bell, G. I. & Davidson, N. O. Fructose transporter in human spermatozoa and small intestine is GLUT5. J. Biol. Chem. 267, 14523–14526 (1992).

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