Abstract
AbstractVariants in ATP1A3 cause neuropsychiatric disorders, especially those characterized by movement disorders. In this study, we performed whole exome sequencing for two patients with movement disorders and identified two novel heterozygous ATP1A3 variants, a missense c.2408G>A variant and an indel c.2672_2688+10delinsCAG variant. The unique indel variant occurred at the exon-intron boundary at the 3′ end of exon 19, and mRNA analysis revealed that this variant caused in-frame indel alteration at the Ser891_Trp896 residue.
Funder
Takeda Science Foundation
MEXT | Japan Society for the Promotion of Science
HUSM Grant-in-Aid from Hamamatsu University School of Medicine
Mochida Memorial Foundation for Medical and Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Biochemistry