LDB2 locus disruption on 4p16.1 as a risk factor for schizophrenia and bipolar disorder-Reference-Cited by-同舟云学术

LDB2 locus disruption on 4p16.1 as a risk factor for schizophrenia and bipolar disorder

Published:2020-09-29 Issue:1 Volume:7 Page:
ISSN:2054-345X
Container-title:Human Genome Variation
language:en
Short-container-title:Hum Genome Var

Author:

Horiuchi Yasue^ORCID,Ichikawa Tomoe,Ohnishi Tetsuo,Iwayama Yoshimi,Toriumi Kazuya,Miyashita Mitsuhiro,Nohara Izumi,Obata Nanako,Toyota Tomoko,Yoshikawa Takeo,Itokawa Masanari,Arai Makoto

Abstract

AbstractWe had previously reported the case of a male patient with schizophrenia, having de-novo balanced translocation. Here, we determined the exact breakpoints in chromosomes 4 and 13. The breakpoint within chromosome 4 was mapped to a region 32.6 kbp upstream of the LDB2 gene encoding Lim domain binding 2. Variant screening in LDB2 revealed a rare novel missense variant in patients with psychiatric disorder.

Funder

SENSHIN Medical Research Foundation

MEXT | Japan Society for the Promotion of Science

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Biochemistry

Link

https://www.nature.com/articles/s41439-020-00117-7.pdf

Reference16 articles.

1. Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014).

2. MacIntyre, D. J., Blackwood, D. H., Porteous, D. J., Pickard, B. S. & Muir, W. J. Chromosomal abnormalities and mental illness. Mol. Psychiatry 8, 275–287 (2003).

3. Singh, T. et al. The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability. Nat. Genet. 49, 1167–1173 (2017).

4. Bipolar, D., Schizophrenia Working Group of the Psychiatric Genomics Consortium. Electronic address drve, Bipolar D, Schizophrenia Working Group of the Psychiatric Genomics C. Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. Cell 173, 1705–1715.e16 (2018).

5. Andlauer T. F. M. et al. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Mol. Psychiatry. https://doi.org/10.1038/s41380-019-0558-2 (2019).

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cooperation of LIM domain‐binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia;EMBO Molecular Medicine;2021-03-03