Targeting Toll-like receptors: emerging therapeutics?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd3203.pdf
Reference152 articles.
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3. Park, B. S. et al. The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex. Nature 458, 1191–1195 (2009). References 3, 6 and 7 are the first studies to illustrate the crystal structures for TLR4, TLR3 and the TLR1–TLR2 heterodimer with their specific ligands.
4. Dziarski, R. & Gupta, D. Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. J. Endotoxin Res. 6, 401–405 (2000).
5. Carpenter, S. & O'Neill, L. A. Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem. J. 422, 1–10 (2009).
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