The Ketamine Metabolite 2R,6R-Hydroxynorketamine Blocks NMDA Receptors and Impacts Downstream Signaling Linked to Antidepressant Effects
Author:
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Pharmacology
Link
http://www.nature.com/articles/npp2017210.pdf
Reference6 articles.
1. Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng P et al (2011). NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 275: 91–95.
2. Maeng S, Zarate CA Jr, Du J, Schloesser RJ, McCammon J, Chen G et al (2008). Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry 63: 349–352.
3. Nosyreva E, Szabla K, Autry AE, Ryazanov AG, Monteggia LM, Kavalali ET (2013). Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J Neurosci 33: 6990–7002.
4. Suzuki K, Nosyreva E, Hunt KW, Kavalali ET, Monteggia LM (2017). The ketamine metabolite hydroxynorketamine impacts downstream signaling via NMDA receptor inhibition. Nature 546: E1–E3.
5. Yang C, Qu Y, Abe M, Nozawa D, Chaki S, Hashimoto K (2017). (R)-Ketamine shows greater potency and longer lasting antidepressant effects than its metabolite (2R,6R)-hydroxynorketamine. Biol Psychiatry 82: e43–e44.
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