COX-2 inhibitors for colorectal cancer

Author:

Elder Douglas J. E.,Paraskeva Christos

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference11 articles.

1. Shift, S.J. & Rigas, B. Nonsteroidal antiinflamma-tory drugs and colorectal cancer: evolving concepts of their chemopreventive actions. Gastroenterology 113 1992–1998 (1997).

2. Kawamori, T., Rao, C.V., Seibert, K. & Reddy, B.S. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res. 58, 409–412 (1998).

3. Williams, C.S. & DuBois, R.N. Prostaglandin endoperoxide synthase: Why two isoforms? Am. J. Physiol 270, G393–G400 (1996).

4. Oshima, M. et al. Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803–809 (1996).

5. Sheng, H., Shao, J., Morrow, J.D., Beauchamp, R.D. & DuBois, R.N. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res. 58, 362–366 (1998).

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