Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease
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Published:2017-10-30
Issue:12
Volume:49
Page:1722-1730
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Lu XiangfengORCID, , Peloso Gina M, Liu Dajiang J, Wu Ying, Zhang He, Zhou Wei, Li Jun, Tang Clara Sze-manORCID, Dorajoo RajkumarORCID, Li Huaixing, Long Jirong, Guo Xiuqing, Xu Ming, Spracklen Cassandra N, Chen Yang, Liu Xuezhen, Zhang Yan, Khor Chiea ChuenORCID, Liu Jianjun, Sun Liang, Wang Laiyuan, Gao Yu-Tang, Hu Yao, Yu Kuai, Wang Yiqin, Cheung Chloe Yu Yan, Wang Feijie, Huang Jianfeng, Fan Qiao, Cai Qiuyin, Chen Shufeng, Shi Jinxiu, Yang Xueli, Zhao Wanting, Sheu Wayne H-H, Cherny Stacey ShawnORCID, He Meian, Feranil Alan B, Adair Linda S, Gordon-Larsen PennyORCID, Du Shufa, Varma Rohit, Chen Yii-Der Ida, Shu Xiao-Ou, Lam Karen Siu Ling, Wong Tien Yin, Ganesh Santhi K, Mo Zengnan, Hveem Kristian, Fritsche Lars G, Nielsen Jonas BilleORCID, Tse Hung-fat, Huo Yong, Cheng Ching-Yu, Chen Y Eugene, Zheng WeiORCID, Tai E Shyong, Gao Wei, Lin Xu, Huang Wei, Abecasis Goncalo, Kathiresan SekarORCID, Mohlke Karen LORCID, Wu Tangchun, Sham Pak Chung, Gu DongfengORCID, Willer Cristen JORCID
Publisher
Springer Science and Business Media LLC
Reference40 articles.
1. Teslovich, T.M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707–713 (2010). 2. Willer, C.J. et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 45, 1274–1283 (2013). 3. Surakka, I. et al. The impact of low-frequency and rare variants on lipid levels. Nat. Genet. 47, 589–597 (2015). 4. Asselbergs, F.W. et al. Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am. J. Hum. Genet. 91, 823–838 (2012). 5. Kim, Y.J. et al. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat. Genet. 43, 990–995 (2011).
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